Q1 . Assertion: Prophylaxis for CNS disease forms an important part of therapy of acute lymphoblastic leukemia

Reason: Symptomatic CNS leukemia is a frequent manifestation at the time of diagnosis

A) Both Assertion and Reason are true, and Reason is the correct explanation for Assertion

B) Both Assertion and Reason are true, and Reason is not the correct explanation for Assertion

C) Assertion is true, but Reason is false

D) Assertion is false, but reason is true

Answer: C

Q2 . Shown below is diagramatic representation of relative dose at different depths for various beam energy levels of ionizing radiation.

Skin sparing effect is most with one of the following beams

A) beam 1

B) beam 2

C) beam 3

D) beam 4

Answer: A

Q3 . Anthracyclines used as anticancer drugs

1.Mitomycin

2.Dactinomycin

3.Bleomycin

4.Mitoxantrone

A) only 1, 2, and 3 are correct

B) only 1 and 3 are correct

C) only 2 and 4 are correct

D) only 4 is correct

Answer: D

Q4 . Assertion: Imatinib (Bcr-Abl tyrosine kinase inhibitor) is effective only when administered in the blast phase of CML

Reason: Imatinib switches off the proliferative signal for the defective stem cell.

A) Both Assertion and Reason are true, and Reason is the correct explanation for Assertion

B) Both Assertion and Reason are true, and Reason is not the correct explanation for Assertion

C) Assertion is true, but Reason is false

D) Assertion is false, but Reason is true

Answer: D

Q5 . The following bone lesions have a potential risk of malignant transformation

1.Osteoid osteoma

2.polyostotic fibrous dysplasia

3.Aneurysmal bone cyst

4.Osteochondroma

A) only 1, 2, and 3 are correct

B) only 1 and 3 are correct

C) only 2 and 4 are correct

D) only 4 is correct

Answer: C

Q6 . Metastatic involvement of the heart is noted in the following malignancy(ies):

1. carcinoma breast

2. leukemia

3. sarcoma

4. thymic carcinoma

A) only 1, 2, and 3 are correct

B) only 1 and 3 are correct

C) only 2 and 4 are correct

D) only 4 is correct

Answer: A

Q7 . Mutations in the genes on the short arm of chromosome 11 are implicated in pathogenesis

1. nephroblastoma

2. retinoblastoma

3. rhabdomyosarcoma

4. renal cell carcinoma

A) only 1, 2, and 3 are correct

B) only 1 and 3 are correct

C) only 2 and 4 are correct

D) only 4 is correct

Answer: B

Q8 . In the process of DNA replication, the unwinding of DNA is done by

A) DNA polymerase

B) DNA primase

C) topoisomerase

D) helicase

Answer: D

Q9 . The upper GI barium series given below is from a 63-year old smoker and alcoholic with a history of easy satiety and anorexia

The lesion is indicative of :

A) atrophic gastritis

B) Menetriers's disease

C) carcinoma of the stomach

D) trichobezoar

Answer: C

Q10 . In lymphomas localised to the thyroid gland

Assertion: Surgery is avoided as initial therapy

Reason:These tumors are highly sensitive to external radiation

A) Both Assertion and Reason are true, and Reason is the correct explanation for Assertion

B) Both Assertion and Reason are true, and Reason is not the correct explanation for Assertion

C) Assertion is true, but Reason is false

D) Assertion is false, but Reason is true

Answer: B

Q11 . In the computed tomography (CT) scan depicted below, the left panel represents a section without contrast whereas the right panel represents that after administration of contrast.

The most probable diagnosis of the left sided renal lesion is

A) angiomyolipoma

B) renal cyst

C) renal cell carcinoma

D) oncocytoma

Answer: B

Q12 . Regarding

Assertion: In the prostate MRI is superior to CT in defining the prostatic apex

Reason: There is lack of discrete capsule at the apex

A) Both Assertion and Reason are true, and Reason is the correct explanation for Assertion

B) Both Assertion and Reason are true, and Reason is not the correct explanation for Assertion

C) Assertion is true, but Reason is false

D) Assertion is false, but Reason is true

Answer: A